|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:actsOn
|
gptkb:GLI_transcription_factors
gptkb:Patched_receptor
gptkb:Smoothened_receptor
gptkb:primary_cilium
|
|
gptkbp:associatedWith
|
gptkb:medulloblastoma
gptkb:rhabdomyosarcoma
pancreatic cancer
prostate cancer
|
|
gptkbp:category
|
signaling molecule
morphogen
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
SHH gene
|
|
gptkbp:expressedIn
|
notochord
floor plate
limb bud
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
embryonic development
cell signaling
pattern formation
|
|
gptkbp:HGNC_ID
|
10848
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sonic Hedgehog protein
|
|
gptkbp:involvedIn
|
gptkb:Hedgehog_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
7q36
|
|
gptkbp:molecularWeight
|
~45 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Gorlin_syndrome
gptkb:holoprosencephaly
basal cell carcinoma
|
|
gptkbp:namedAfter
|
gptkb:Sonic_the_Hedgehog
|
|
gptkbp:OMIM
|
600725
|
|
gptkbp:orthologIn
|
Desert Hedgehog protein
Indian Hedgehog protein
|
|
gptkbp:pathway
|
canonical Hedgehog pathway
non-canonical Hedgehog pathway
|
|
gptkbp:PDB
|
3M1N
|
|
gptkbp:postTranslationalModification
|
palmitoylation
cholesterol modification
|
|
gptkbp:recipient
|
gptkb:Smoothened_(SMO)
Patched (PTCH1)
|
|
gptkbp:requires
|
craniofacial development
somite patterning
ventral neural tube development
|
|
gptkbp:role
|
left-right asymmetry
neural tube patterning
digit formation
|
|
gptkbp:symbol
|
gptkb:SHH
|
|
gptkbp:UniProtID
|
gptkb:Q15465
|
|
gptkbp:bfsParent
|
gptkb:SHH
|
|
gptkbp:bfsLayer
|
7
|