|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:actsOn
|
gptkb:Patched_receptor
gptkb:Smoothened_receptor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:holoprosencephaly
basal cell carcinoma
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
SHH gene
|
|
gptkbp:Entrez_Gene_ID
|
6469
|
|
gptkbp:expressedIn
|
notochord
gastrulation
floor plate
limb bud
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signaling molecule
|
|
gptkbp:HGNC_ID
|
10848
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sonic Hedgehog
|
|
gptkbp:involvedIn
|
cell differentiation
embryonic development
pattern formation
|
|
gptkbp:locatedOnChromosome
|
7q36
|
|
gptkbp:memberOf
|
gptkb:Hedgehog_signaling_pathway
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Gorlin_syndrome
polydactyly
cyclopia
|
|
gptkbp:namedAfter
|
gptkb:Sonic_the_Hedgehog
|
|
gptkbp:OMIM
|
600725
|
|
gptkbp:orthologIn
|
Drosophila melanogaster (Hedgehog protein)
|
|
gptkbp:PDB
|
3M1N
|
|
gptkbp:postTranslationalModification
|
palmitoylation
cholesterol modification
|
|
gptkbp:regulates
|
hair follicle development
neural tube patterning
digit formation
|
|
gptkbp:relatedTo
|
Desert Hedgehog
Indian Hedgehog
|
|
gptkbp:requires
|
craniofacial development
left-right asymmetry
ventral neural tube development
|
|
gptkbp:reviewedBy
|
gptkb:Nature
gptkb:science
Cell
|
|
gptkbp:symbol
|
gptkb:SHH
|
|
gptkbp:target
|
gptkb:sonidegib
gptkb:vismodegib
cancer therapeutics
|
|
gptkbp:UniProtID
|
gptkb:Q15465
|
|
gptkbp:bfsParent
|
gptkb:SHH
|
|
gptkbp:bfsLayer
|
7
|