|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:5-HTT
gptkb:serotonin_transporter
|
|
gptkbp:associatedWith
|
gptkb:depression
gptkb:autism_spectrum_disorder
gptkb:obsessive-compulsive_disorder
anxiety disorder
serotonergic synapse
|
|
gptkbp:component
|
gptkb:plasma_membrane
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000108576
6532
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:placenta
brain
intestine
|
|
gptkbp:family
|
gptkb:solute_carrier_family_6
|
|
gptkbp:function
|
serotonin:sodium symporter activity
transports serotonin from synaptic spaces into presynaptic neurons
|
|
gptkbp:gene
|
gptkb:SLC6A4
|
|
gptkbp:GOProcess
|
serotonin uptake
|
|
gptkbp:hasPolymorphism
|
gptkb:5-HTTLPR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
S6A4 HUMAN
|
|
gptkbp:inhibitedBy
|
gptkb:tricyclic_antidepressants
gptkb:selective_serotonin_reuptake_inhibitors
|
|
gptkbp:length
|
630 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17q11.2
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
70 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Slc6a4
gptkb:rat_Slc6a4
|
|
gptkbp:PDB
|
6VRH
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:publicTransit
|
neurotransmitter:sodium symporter
|
|
gptkbp:RefSeq
|
gptkb:NM_001045
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:substrate
|
serotonin
|
|
gptkbp:targetOfDrug
|
antidepressants
anxiolytics
|
|
gptkbp:UniProtID
|
gptkb:P31645
|
|
gptkbp:bfsParent
|
gptkb:P31645
|
|
gptkbp:bfsLayer
|
7
|