Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
gptkb:cancer
neurodegenerative diseases cardiovascular diseases inflammatory diseases |
| gptkbp:binds |
calcium ions
copper ions zinc ions |
| gptkbp:contains |
EF-hand calcium-binding motif
|
| gptkbp:discoveredIn |
1965
|
| gptkbp:example |
gptkb:S100B
gptkb:S100A1 gptkb:S100A2 gptkb:S100A4 gptkb:S100A6 gptkb:S100A8 gptkb:S100A9 gptkb:S100P |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
apoptosis
cell cycle progression cell migration inflammatory response regulation of protein phosphorylation regulation of transcription factors regulation of cell growth and differentiation regulation of cytoskeleton dynamics regulation of enzyme activities |
| https://www.w3.org/2000/01/rdf-schema#label |
S100 protein family
|
| gptkbp:locatedOnChromosome |
chromosome 1q21 (many members)
|
| gptkbp:memberOf |
EF-hand superfamily
|
| gptkbp:namedAfter |
solubility in 100% saturated ammonium sulfate
|
| gptkbp:numberOfMembers |
at least 21
|
| gptkbp:regulates |
immune response
neuronal survival cellular differentiation cellular energy metabolism cellular proliferation cellular apoptosis cellular motility inflammatory processes astrocyte function cellular calcium homeostasis |
| gptkbp:structure |
dimeric proteins
|
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm extracellular space |
| gptkbp:usedAs |
biomarker in clinical diagnostics
|
| gptkbp:bfsParent |
gptkb:CGRN
|
| gptkbp:bfsLayer |
6
|