Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
42A
calvasculin metastasin pEL98 |
| gptkbp:associatedWith |
gptkb:cancer
colorectal cancer pancreatic cancer osteosarcoma fibrosis cancer metastasis |
| gptkbp:discoveredBy |
1989
|
| gptkbp:encodes |
S100 calcium-binding protein A4
|
| gptkbp:Entrez_Gene_ID |
6275
ENSG00000196154 |
| gptkbp:expressedIn |
fibroblasts
tumor cells |
| gptkbp:family |
gptkb:S100_protein_family
|
| gptkbp:function |
regulation of cell motility
calcium binding regulation of cell invasion regulation of metastasis |
| gptkbp:gene |
gptkb:S100A4
|
| gptkbp:HGNC_ID |
HGNC:10489
|
| gptkbp:interactsWith |
gptkb:tropomyosin
gptkb:p53 Annexin II liprin beta-1 non-muscle myosin II |
| gptkbp:locatedOnChromosome |
1
|
| gptkbp:location |
1q21.3
|
| gptkbp:molecularWeight |
11.5 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
S100a4
|
| gptkbp:pathway |
cell migration
metastatic signaling |
| gptkbp:postTranslationalModification |
phosphorylation
acetylation |
| gptkbp:regulates |
regulated by p53
regulated by TGF-beta upregulated in metastatic tumors |
| gptkbp:relatedTo |
epithelial-mesenchymal transition
|
| gptkbp:structure |
contains two EF-hand calcium-binding motifs
|
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm extracellular space |
| gptkbp:UniProtID |
P26447
|
| gptkbp:bfsParent |
gptkb:S-100_protein
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
S100A4
|