|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
42A
calvasculin
metastasin
pEL98
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
osteosarcoma
fibrosis
cancer metastasis
|
|
gptkbp:discoveredBy
|
1989
|
|
gptkbp:encodes
|
S100 calcium-binding protein A4
|
|
gptkbp:Entrez_Gene_ID
|
6275
ENSG00000196154
|
|
gptkbp:expressedIn
|
fibroblasts
tumor cells
|
|
gptkbp:family
|
gptkb:S100_protein_family
|
|
gptkbp:function
|
regulation of cell motility
calcium binding
regulation of cell invasion
regulation of metastasis
|
|
gptkbp:gene
|
gptkb:S100A4
|
|
gptkbp:HGNC_ID
|
HGNC:10489
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
S100A4
|
|
gptkbp:interactsWith
|
gptkb:tropomyosin
gptkb:p53
Annexin II
liprin beta-1
non-muscle myosin II
|
|
gptkbp:locatedOnChromosome
|
1
|
|
gptkbp:location
|
1q21.3
|
|
gptkbp:molecularWeight
|
11.5 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
S100a4
|
|
gptkbp:pathway
|
cell migration
metastatic signaling
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:regulates
|
regulated by p53
regulated by TGF-beta
upregulated in metastatic tumors
|
|
gptkbp:relatedTo
|
epithelial-mesenchymal transition
|
|
gptkbp:structure
|
contains two EF-hand calcium-binding motifs
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
extracellular space
|
|
gptkbp:UniProtID
|
P26447
|
|
gptkbp:bfsParent
|
gptkb:S-100_protein
gptkb:S100_protein
gptkb:S100_protein_family
|
|
gptkbp:bfsLayer
|
7
|