|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
S100 calcium-binding protein A1
S100-alpha
|
|
gptkbp:associatedWith
|
heart failure
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:domain
|
EF-hand calcium-binding domain
|
|
gptkbp:encodedBy
|
S100A1 gene
|
|
gptkbp:Entrez_Gene_ID
|
6271
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
|
|
gptkbp:function
|
regulation of cellular processes
calcium-binding
|
|
gptkbp:HGNC_ID
|
HGNC:10594
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
S100A1
|
|
gptkbp:interactsWith
|
gptkb:RYR2
gptkb:titin
SERCA2A
|
|
gptkbp:involvedIn
|
apoptosis
cell proliferation
muscle contraction
energy metabolism
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1q21
1q21.3
|
|
gptkbp:memberOf
|
gptkb:S100_protein_family
|
|
gptkbp:molecularWeight
|
10.5 kDa
|
|
gptkbp:mutationAssociatedWith
|
cardiomyopathy
|
|
gptkbp:OMIM
|
176940
|
|
gptkbp:orthologInMouse
|
S100a1
|
|
gptkbp:orthologInZebrafish
|
s100a1a
s100a1b
|
|
gptkbp:PDB
|
2LP3
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:regulates
|
cell survival
mitochondrial function
cellular energy production
myocardial contractility
calcium homeostasis
vascular tone
endothelial function
calcium cycling in cardiomyocytes
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:UniProtID
|
P23297
|
|
gptkbp:bfsParent
|
gptkb:S-100_protein
gptkb:S100_protein
gptkb:S100_protein_family
|
|
gptkbp:bfsLayer
|
7
|