Ribosomal protein S6 kinase beta-1

URI: https://gptkb.org/entity/Ribosomal_protein_S6_kinase_beta-1
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy gptkb:mTOR_pathway
gptkbp:alsoKnownAs gptkb:S6K1
p70S6 kinase
gptkbp:associatedWith gptkb:cancer
gptkb:diabetes
obesity
gptkbp:encodedBy gptkb:RPS6KB1_gene
gptkbp:enzymeCommissionNumber 2.7.11.1
gptkbp:expressedIn many tissues
gptkbp:family gptkb:AGC_protein_kinase_family
gptkbp:function serine/threonine kinase
phosphorylates ribosomal protein S6
https://www.w3.org/2000/01/rdf-schema#label Ribosomal protein S6 kinase beta-1
gptkbp:inhibitedBy gptkb:rapamycin
gptkb:PF-4708671
gptkbp:involvedIn cell proliferation
cell growth
protein synthesis regulation
gptkbp:locatedOnChromosome 17q23.1
gptkbp:molecularWeight 70 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 3A62
gptkbp:phosphorylates Ser371
Ser411
Ser424
Ser427
Thr389
gptkbp:regulates insulin signaling
translation initiation
cell size
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:substrate gptkb:BAD
gptkb:IRS1
gptkb:ribosomal_protein_S6
gptkb:PDCD4
gptkb:eIF4B
gptkbp:UniProtID P23443
gptkbp:bfsParent gptkb:S6K1
gptkbp:bfsLayer 6