|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:database
|
HGNC:3289
NCBI Gene:1975
UniProt:P23588
|
|
gptkbp:fullName
|
Eukaryotic translation initiation factor 4B
|
|
gptkbp:function
|
RNA binding
translation initiation
stimulation of RNA helicase activity
|
|
gptkbp:gene
|
EIF4B
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
eIF4B
|
|
gptkbp:interactsWith
|
gptkb:eIF4A
ribosome
eIF3
|
|
gptkbp:locale
|
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
12q13
|
|
gptkbp:molecularWeight
|
80 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
translation initiation
|
|
gptkbp:phosphorylates
|
regulated by RSK
regulated by S6K
|
|
gptkbp:regulates
|
phosphorylation-dependent
|
|
gptkbp:sequence
|
UniProt:P23588
|
|
gptkbp:significance
|
overexpressed in some cancers
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
gptkb:yeast
|
|
gptkbp:structure
|
contains RNA recognition motif
contains arginine-rich region
|
|
gptkbp:bfsParent
|
gptkb:Ribosomal_protein_S6_kinase
gptkb:Ribosomal_protein_S6_kinase_beta-1
gptkb:p70_ribosomal_S6_kinase
|
|
gptkbp:bfsLayer
|
7
|