|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
sympathetic nervous system
low blood pressure
low sodium concentration
|
|
gptkbp:alsoKnownAs
|
gptkb:RAS
|
|
gptkbp:component
|
gptkb:juxtaglomerular_cells
adrenal cortex
vascular smooth muscle
macula densa
|
|
gptkbp:discoveredBy
|
gptkb:Eduardo_Braun-Menéndez
gptkb:Irvine_Page
gptkb:Leonardo_Rosenfeld
|
|
gptkbp:discoveredIn
|
1930s
|
|
gptkbp:dysregulationAssociatedWith
|
heart failure
hypertension
chronic kidney disease
|
|
gptkbp:effect
|
water retention
vasoconstriction
increased blood pressure
sodium retention
|
|
gptkbp:function
|
maintain blood pressure homeostasis
regulate extracellular fluid volume
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Renin-Angiotensin System
|
|
gptkbp:inhibitedBy
|
gptkb:spironolactone
gptkb:angiotensin_receptor_blockers
gptkb:aliskiren
gptkb:eplerenone
ACE inhibitors
|
|
gptkbp:involves
|
gptkb:renin
gptkb:angiotensin-converting_enzyme
gptkb:angiotensin_I
gptkb:angiotensin_II
gptkb:aldosterone
gptkb:angiotensinogen
|
|
gptkbp:location
|
gptkb:kidney
lungs
liver
adrenal glands
|
|
gptkbp:recipient
|
gptkb:AT1_receptor
gptkb:AT2_receptor
|
|
gptkbp:regulates
|
blood pressure
fluid balance
|
|
gptkbp:relatedTo
|
sympathetic nervous system
aldosterone system
natriuretic peptide system
|
|
gptkbp:target
|
gptkb:angiotensin_receptor_blockers
ACE inhibitors
|
|
gptkbp:bfsParent
|
gptkb:Blood_Pressure
|
|
gptkbp:bfsLayer
|
7
|