aliskiren

URI: https://gptkb.org/entity/aliskiren

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:renin_inhibitor gptkb:drug
gptkbp:approvalYear	2007
gptkbp:ATCCode	C09XA02
gptkbp:bioavailability	2.5%
gptkbp:brand	Rasilez Tekturna
gptkbp:CASNumber	173334-57-1
gptkbp:category	gptkb:antihypertensive_agent renin–angiotensin system inhibitor
gptkbp:contraindication	pregnancy concomitant use with ACE inhibitors in diabetes
gptkbp:developer	gptkb:Novartis
gptkbp:discoveredBy	gptkb:Novartis
gptkbp:eliminationHalfLife	24 hours
gptkbp:excretion	feces
gptkbp:firstBook	yes
gptkbp:hasMolecularFormula	C30H53N3O6
gptkbp:IUPACName	(2S,4S,5S,7S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide
gptkbp:KEGGID	D07454
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	direct renin inhibition
gptkbp:MeSH_ID	D000068879
gptkbp:metabolism	gptkb:CYP3A4
gptkbp:pregnancyCategory	D (US)
gptkbp:proteinBinding	47-51%
gptkbp:PubChem_CID	gptkb:CHEMBL1201197 4591676 5492044 DB01258
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	gptkb:angioedema diarrhea hyperkalemia
gptkbp:UNII	8C2K2VUD7I
gptkbp:usedFor	hypertension
gptkbp:bfsParent	gptkb:valsartan gptkb:olmesartan
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	aliskiren