|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
leukemia
melanoma
pancreatic cancer
|
|
gptkbp:contains
|
gptkb:GTP-binding_domain
|
|
gptkbp:database
|
gptkb:UniProt:P01112
gptkb:InterPro:IPR001806
gptkb:Pfam:PF00071
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:family
|
gptkb:Ras_superfamily
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
GTPase activity
|
|
gptkbp:gene
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
gptkb:RAN
gptkb:RAB1A
gptkb:ARF1
gptkb:RHOA
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras-related protein
|
|
gptkbp:involvedIn
|
cell differentiation
cell survival
cell growth regulation
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~21 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic transformation
|
|
gptkbp:orthologIn
|
gptkb:C._elegans_Ras_proteins
gptkb:Drosophila_Ras_proteins
gptkb:yeast_Ras_proteins
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:regulates
|
gptkb:guanine_nucleotide_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs)
guanine nucleotide exchange factors (GEFs)
GTP/GDP binding
|
|
gptkbp:relatedTo
|
gptkb:cancer
oncogenesis
|
|
gptkbp:role
|
signal transduction
|
|
gptkbp:structure
|
small GTPase domain
|
|
gptkbp:subfamily
|
gptkb:Rab
gptkb:Ran
gptkb:Arf
gptkb:Ras
gptkb:Rho
|
|
gptkbp:bfsParent
|
gptkb:Ras85D
gptkb:Ras85D-RL
|
|
gptkbp:bfsLayer
|
6
|