Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
mutant
|
| gptkbp:activatedBy |
gptkb:MAPK/ERK_pathway
|
| gptkbp:aminoAcidChange |
1799T>A
valine to glutamic acid at position 600 |
| gptkbp:associatedWith |
gptkb:hairy_cell_leukemia
gptkb:lung_adenocarcinoma gptkb:papillary_thyroid_carcinoma colorectal cancer melanoma |
| gptkbp:Entrez_Gene_ID |
gptkb:rs113488022
|
| gptkbp:firstDescribed |
2002
|
| gptkbp:foundIn |
solid tumors
hematologic malignancies |
| https://www.w3.org/2000/01/rdf-schema#label |
BRAF V600E
|
| gptkbp:mutationAssociatedWith |
missense mutation
|
| gptkbp:prevalenceInColorectalCancer |
~10%
|
| gptkbp:prevalenceInMelanoma |
~50%
|
| gptkbp:prevalenceInPapillaryThyroidCarcinoma |
~40-60%
|
| gptkbp:regulates |
gptkb:BRAF
|
| gptkbp:resistantTo |
gptkb:EGFR_inhibitors_(in_colorectal_cancer)
|
| gptkbp:sensitivity |
gptkb:encorafenib
gptkb:dabrafenib gptkb:vemurafenib |
| gptkbp:significance |
predictive marker
prognostic marker |
| gptkbp:target |
gptkb:BRAF_inhibitors
gptkb:MEK_inhibitors |
| gptkbp:bfsParent |
gptkb:RAF_kinase
|
| gptkbp:bfsLayer |
5
|