Rapidly Accelerated Fibrosarcoma kinase
GPTKB entity
Statements (30)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:protein
|
gptkbp:abbreviation |
gptkb:RAF_kinase
|
gptkbp:activatedBy |
gptkb:RAS
|
gptkbp:discoveredBy |
gptkb:Lewis_T._Williams
|
gptkbp:discoveredIn |
1983
|
gptkbp:encodedBy |
gptkb:RAF_gene_family
|
gptkbp:function |
signal transduction
regulation of cell division |
gptkbp:hasIsoform |
gptkb:ARAF
gptkb:BRAF gptkb:CRAF |
https://www.w3.org/2000/01/rdf-schema#label |
Rapidly Accelerated Fibrosarcoma kinase
|
gptkbp:involvedIn |
gptkb:MAPK/ERK_pathway
|
gptkbp:locale |
gptkb:cell_membrane
gptkb:cytoplasm |
gptkbp:memberOf |
serine/threonine protein kinase family
|
gptkbp:mutationAssociatedWith |
gptkb:cancer
colorectal cancer melanoma |
gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens gptkb:Drosophila_melanogaster |
gptkbp:phosphorylates |
gptkb:MEK
|
gptkbp:regulates |
cell differentiation
cell proliferation |
gptkbp:target |
gptkb:dabrafenib
gptkb:vemurafenib kinase inhibitors |
gptkbp:bfsParent |
gptkb:RAF_kinase
|
gptkbp:bfsLayer |
5
|