Rapidly Accelerated Fibrosarcoma kinase
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:RAF_kinase
|
| gptkbp:activatedBy |
gptkb:RAS
|
| gptkbp:discoveredBy |
gptkb:Lewis_T._Williams
|
| gptkbp:discoveredIn |
1983
|
| gptkbp:encodedBy |
gptkb:RAF_gene_family
|
| gptkbp:function |
signal transduction
regulation of cell division |
| gptkbp:hasIsoform |
gptkb:ARAF
gptkb:BRAF gptkb:CRAF |
| gptkbp:involvedIn |
gptkb:MAPK/ERK_pathway
|
| gptkbp:locale |
gptkb:cell_membrane
gptkb:cytoplasm |
| gptkbp:memberOf |
serine/threonine protein kinase family
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:melanoma colorectal cancer |
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens gptkb:Drosophila_melanogaster |
| gptkbp:phosphorylates |
gptkb:MEK
|
| gptkbp:regulates |
cell differentiation
cell proliferation |
| gptkbp:target |
gptkb:dabrafenib
gptkb:vemurafenib kinase inhibitors |
| gptkbp:bfsParent |
gptkb:RAF_kinase
|
| gptkbp:bfsLayer |
5
|
| https://www.w3.org/2000/01/rdf-schema#label |
Rapidly Accelerated Fibrosarcoma kinase
|