|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activity
|
gptkb:ATPase
DNA-dependent ATPase
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:RAD51_gene
|
|
gptkbp:Entrez_Gene_ID
|
5888
ENSG00000051180
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:family
|
RecA/RAD51 family
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
DNA repair
homologous recombination
|
|
gptkbp:GO
|
GO:0005515 (protein binding)
GO:0000724 (double-strand break repair via homologous recombination)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAD51 protein
|
|
gptkbp:inhibitedBy
|
gptkb:B02
RI-1
|
|
gptkbp:interactsWith
|
gptkb:BRCA2_protein
RAD52 protein
RPA protein
|
|
gptkbp:involvedIn
|
meiotic recombination
mitotic recombination
|
|
gptkbp:KEGGID
|
hsa:5888
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
15q15.1
|
|
gptkbp:molecularWeight
|
~37 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer susceptibility
|
|
gptkbp:OMIM
|
179617
|
|
gptkbp:orthologIn
|
Escherichia coli RecA protein
Saccharomyces cerevisiae Rad51p
|
|
gptkbp:overexpressedIn
|
tumor progression
|
|
gptkbp:PDB
|
1N0W
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
|
|
gptkbp:proteinFamily
|
PF08423
|
|
gptkbp:Reactome
|
R-HSA-5693532
|
|
gptkbp:regulates
|
gptkb:BRCA1_protein
gptkb:p53_protein
|
|
gptkbp:requires
|
sister chromatid exchange
genome stability
DNA strand exchange
DNA strand invasion
|
|
gptkbp:sequence
|
339 amino acids
|
|
gptkbp:significance
|
biomarker for cancer
|
|
gptkbp:structure
|
forms nucleoprotein filaments
|
|
gptkbp:subunit
|
monomer, forms helical filaments
|
|
gptkbp:UniProtID
|
gptkb:Q06609
|
|
gptkbp:usedIn
|
cancer therapy research
|
|
gptkbp:bfsParent
|
gptkb:BRCA1_protein
|
|
gptkbp:bfsLayer
|
7
|