Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
HsRAD51
R51H RecA homolog |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:Fanconi_anemia Fanconi anemia-like disorder breast-ovarian cancer congenital mirror movement disorder |
| gptkbp:conservedIn |
eukaryotes
|
| gptkbp:encodes |
gptkb:RAD51_protein
|
| gptkbp:Entrez_Gene_ID |
5888
ENSG00000051180 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:firstDescribed |
1993
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
DNA binding
ATPase activity strand exchange during homologous recombination |
| gptkbp:geneType |
protein-coding
|
| gptkbp:hasTranscriptVariant |
multiple
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAD51 gene
|
| gptkbp:interactsWith |
gptkb:BRCA1_protein
gptkb:BRCA2_protein RAD52 protein RAD54 protein |
| gptkbp:involvedIn |
DNA repair
homologous recombination |
| gptkbp:length |
10 exons
339 amino acids |
| gptkbp:locatedOnChromosome |
15q15.1
|
| gptkbp:mutationAssociatedWith |
genomic instability
cancer predisposition |
| gptkbp:OMIM |
179617
|
| gptkbp:orthologIn |
Arabidopsis AtRAD51
Drosophila spnA Rad51 (yeast) mouse Rad51 yeast Rad51 |
| gptkbp:pathway |
DNA double-strand break repair
homologous recombination repair |
| gptkbp:proteinFamily |
gptkb:Walker_A_motif
gptkb:Walker_B_motif RecA/RAD51 family RecA-like domain |
| gptkbp:regulates |
genome stability
regulated by p53 cell cycle dependent regulated by BRCA2 |
| gptkbp:UniProtID |
gptkb:Q06609
|
| gptkbp:bfsParent |
gptkb:RAD51
|
| gptkbp:bfsLayer |
7
|