|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
adenosine triphosphatase
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:discoveredBy
|
gptkb:Jens_Christian_Skou
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:EC_number
|
3.6.1.3
|
|
gptkbp:example
|
Ca2+-ATPase
F-ATPase
H+/K+-ATPase
Na+/K+-ATPase
V-ATPase
P-ATPase
|
|
gptkbp:foundIn
|
gptkb:cell_membrane
gptkb:cytoplasm
chloroplast
mitochondria
|
|
gptkbp:function
|
catalyzes hydrolysis of ATP
|
|
gptkbp:GO_term
|
gptkb:GO:0016887
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ATPase
|
|
gptkbp:inhibitedBy
|
gptkb:ouabain
vanadate
|
|
gptkbp:mechanismOfAction
|
conformational change
phosphorylation-dephosphorylation cycle
|
|
gptkbp:presentIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:product
|
gptkb:ADP
inorganic phosphate
|
|
gptkbp:role
|
muscle contraction
cellular homeostasis
ion transport
energy transduction
|
|
gptkbp:significance
|
involved in hypertension
involved in cystic fibrosis
target for cardiac glycosides
|
|
gptkbp:structure
|
contains nucleotide-binding domain
contains transmembrane domain
|
|
gptkbp:substrate
|
gptkb:ATP
|
|
gptkbp:type
|
gptkb:cell_membrane
motor protein
|
|
gptkbp:bfsParent
|
gptkb:CHEBI:17716
gptkb:CHEBI:18185
gptkb:CHEBI:17336
|
|
gptkbp:bfsLayer
|
6
|