|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
MRP8
calgranulin A
S100 calcium-binding protein A8
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
S100A8 gene
|
|
gptkbp:expressedIn
|
monocytes
neutrophils
|
|
gptkbp:formsComplexWith
|
calprotectin
Protein S100-A9
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
inflammatory response
calcium binding
|
|
gptkbp:hasBiomarker
|
inflammatory diseases
rheumatoid arthritis
inflammatory bowel disease
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Protein S100-A8
|
|
gptkbp:interactsWith
|
gptkb:TLR4
gptkb:RAGE
|
|
gptkbp:involvedIn
|
immune response
leukocyte migration
antimicrobial activity
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1q21
|
|
gptkbp:location
|
gptkb:cytoplasm
extracellular space
|
|
gptkbp:memberOf
|
gptkb:S100_protein_family
|
|
gptkbp:molecularWeight
|
10.8 kDa
|
|
gptkbp:PDB
|
1MR8
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
|
|
gptkbp:structure
|
EF-hand calcium-binding domain
|
|
gptkbp:UniProtID
|
P05109
|
|
gptkbp:bfsParent
|
gptkb:P05121
gptkb:P45452
gptkb:ENSG00000105369
gptkb:NP_003047.2
gptkb:P46777
gptkb:P40480
gptkb:P35462
gptkb:P33681
gptkb:P21964
gptkb:P82279
|
|
gptkbp:bfsLayer
|
8
|