Polo-like kinase 1 (PLK1)

URI: https://gptkb.org/entity/Polo-like_kinase_1_(PLK1)
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:PLK
PLK-1
STPK13
Serine/threonine-protein kinase PLK1
gptkbp:associatedWith gptkb:cancer
gptkbp:biologicalProcess DNA damage response
apoptosis regulation
serine/threonine kinase activity
chromosome segregation
G2/M transition of mitotic cell cycle
gptkbp:cellularComponent gptkb:nucleus
centrosome
spindle pole
gptkbp:clinicalTrialPhase PLK1 inhibitors in cancer therapy
gptkbp:discoveredBy L. Nigg
gptkbp:encodedBy PLK1 gene
gptkbp:Entrez_Gene_ID 5347
gptkbp:enzymeClassification EC 2.7.11.21
gptkbp:function regulation of cell cycle
mitosis
cytokinesis
spindle formation
gptkbp:gene gptkb:PLK1
gptkbp:HGNC_ID 9077
https://www.w3.org/2000/01/rdf-schema#label Polo-like kinase 1 (PLK1)
gptkbp:inhibitedBy BI 2536
GSK461364
volasertib
gptkbp:locatedOnChromosome gptkb:16p12.2
gptkbp:namedAfter Drosophila polo gene
gptkbp:OMIM 602098
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse Plk1
gptkbp:overexpressedIn various tumors
gptkbp:PDB 2RKU
3FC2
gptkbp:phosphorylates gptkb:CDC25C
gptkb:BUB1
gptkb:NPM1
Cohesin
WEE1
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:regulates activated by phosphorylation
degraded by APC/C
gptkbp:structure contains kinase domain
contains polo-box domain
gptkbp:UniProtID P53350
gptkbp:bfsParent gptkb:Emi1
gptkbp:bfsLayer 7