|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
B23
Nucleolar phosphoprotein B23
Numatrin
|
|
gptkbp:discoveredBy
|
H. Busch et al.
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:encodedBy
|
gptkb:NPM1_gene
|
|
gptkbp:Entrez_Gene_ID
|
4869
ENSG00000181163
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Nucleophosmin
|
|
gptkbp:function
|
cell proliferation
ribosome biogenesis
centrosome duplication
regulation of ARF tumor suppressor
histone chaperone activity
|
|
gptkbp:HGNC_ID
|
7910
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NPM1
|
|
gptkbp:interactsWith
|
gptkb:ARF
gptkb:p53
gptkb:nucleolin
HDM2
|
|
gptkbp:locatedIn
|
gptkb:nucleus
nucleolus
|
|
gptkbp:locatedOnChromosome
|
5q35
|
|
gptkbp:molecularWeight
|
approximately 37 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:acute_myeloid_leukemia
frameshift mutation
insertion mutation
|
|
gptkbp:OMIM
|
164040
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
apoptosis
DNA repair
cell cycle regulation
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:role
|
solid tumors
oncogenesis
hematological malignancies
|
|
gptkbp:structure
|
oligomeric
|
|
gptkbp:subcellularLocation
|
nucleolus
cytoplasm (in mutated form)
|
|
gptkbp:UniProtID
|
P06748
|
|
gptkbp:bfsParent
|
gptkb:ALK_rearrangement
|
|
gptkbp:bfsLayer
|
5
|