|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
BUB1 mitotic checkpoint serine/threonine kinase
Budding uninhibited by benzimidazoles 1 homolog
|
|
gptkbp:associatedWith
|
Mosaic variegated aneuploidy syndrome 1
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
mitotic spindle assembly checkpoint
|
|
gptkbp:cellularComponent
|
kinetochore
|
|
gptkbp:chromosomeArm
|
2q14
|
|
gptkbp:discoveredBy
|
1998
|
|
gptkbp:Entrez_Gene_ID
|
699
ENSG00000169679
|
|
gptkbp:expressedIn
|
all dividing cells
|
|
gptkbp:fullName
|
Mitotic checkpoint serine/threonine-protein kinase BUB1
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
mitotic spindle checkpoint
regulation of chromosome segregation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
BUB1-201
BUB1-202
|
|
gptkbp:HGNC_ID
|
HGNC:1148
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BUB1
|
|
gptkbp:interactsWith
|
gptkb:CDC20
gptkb:BUB3
gptkb:PLK1
MAD1L1
|
|
gptkbp:is_target_of
|
Aurora B kinase
|
|
gptkbp:KEGG_Gene_ID
|
hsa:699
|
|
gptkbp:length
|
1085
|
|
gptkbp:locale
|
kinetochore
|
|
gptkbp:locatedOnChromosome
|
2
|
|
gptkbp:molecularWeight
|
120 kDa
|
|
gptkbp:mutationAssociatedWith
|
chromosomal instability
aneuploidy
|
|
gptkbp:OMIM
|
602452
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Bub1
|
|
gptkbp:orthologInYeast
|
gptkb:BUB1
|
|
gptkbp:PDB
|
4R8Q
|
|
gptkbp:phosphorylates
|
gptkb:CDC20
gptkb:BUBR1
|
|
gptkbp:Reactome
|
R-HSA-141444
|
|
gptkbp:RefSeq
|
NM_004336
NP_004327
|
|
gptkbp:regulates
|
anaphase onset
spindle assembly checkpoint
chromosome alignment
|
|
gptkbp:relatedTo
|
mitosis
cell cycle
|
|
gptkbp:UniProtID
|
O43683
|
|
gptkbp:bfsParent
|
gptkb:MPS1
|
|
gptkbp:bfsLayer
|
7
|