Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
antineoplastic agent |
| gptkbp:administeredBy |
intravenous infusion
|
| gptkbp:alternativeName |
gptkb:Paclitaxel
NSC 125973 Taxus brevifolia extract |
| gptkbp:ATCCode |
L01CD01
|
| gptkbp:brand |
gptkb:Paclitaxel
|
| gptkbp:CASNumber |
33069-62-4
|
| gptkbp:category |
natural product
antineoplastic agent terpenoid mitotic inhibitor plant alkaloid microtubule-stabilizing agent |
| gptkbp:chemicalFormula |
C47H51NO14
|
| gptkbp:contraindication |
hypersensitivity to paclitaxel
severe neutropenia |
| gptkbp:derivedFrom |
gptkb:Pacific_yew
|
| gptkbp:discoveredBy |
gptkb:Mansukh_C._Wani
gptkb:Monroe_E._Wall |
| gptkbp:discoveredIn |
1967
|
| gptkbp:firstFDAApproval |
1992
|
| https://www.w3.org/2000/01/rdf-schema#label |
Taxol
|
| gptkbp:IUPACName |
(2aR,4S,4aS,6R,9S,11S,12aR,12bS)-11-acetoxy-12b-benzoyloxy-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyloxy]-4,6-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2,2a,3,4,4a,5,6,9,10,11,12,12a,12b-tetradecahydro-1H-7,11-methanocyclodeca[3,4]benz[1,2-b]oxet-9-yl benzoate
|
| gptkbp:KEGGID |
D05367
|
| gptkbp:legalStatus |
prescription only
off-patent |
| gptkbp:mechanismOfAction |
inhibits cell division
stabilizes microtubules |
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
853.9 g/mol
|
| gptkbp:origin |
bark of Taxus brevifolia
|
| gptkbp:pregnancyCategory |
D (US)
|
| gptkbp:producedBy |
gptkb:Bristol-Myers_Squibb
|
| gptkbp:PubChem_CID |
gptkb:CHEMBL92
36314 DB01229 |
| gptkbp:routeOfAdministration |
intravenous
|
| gptkbp:sideEffect |
nausea
hair loss neutropenia allergic reactions |
| gptkbp:solubility |
insoluble in water
|
| gptkbp:UNII |
C376O5M5SL
|
| gptkbp:usedFor |
gptkb:cancer
gptkb:Kaposi's_sarcoma |
| gptkbp:bfsParent |
gptkb:taxol
|
| gptkbp:bfsLayer |
5
|