Taxol

URI: https://gptkb.org/entity/Taxol

GPTKB entity

Statements (49)

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound gptkb:antineoplastic_agent
gptkbp:administeredBy	intravenous infusion
gptkbp:alternativeName	gptkb:Paclitaxel NSC 125973 Taxus brevifolia extract
gptkbp:ATCCode	L01CD01
gptkbp:brand	gptkb:Paclitaxel
gptkbp:CASNumber	33069-62-4
gptkbp:category	gptkb:natural_product gptkb:terpenoid gptkb:antineoplastic_agent gptkb:mitotic_inhibitor plant alkaloid microtubule-stabilizing agent
gptkbp:chemicalFormula	C47H51NO14
gptkbp:contraindication	hypersensitivity to paclitaxel severe neutropenia
gptkbp:derivedFrom	gptkb:Pacific_yew
gptkbp:discoveredBy	gptkb:Mansukh_C._Wani gptkb:Monroe_E._Wall
gptkbp:discoveredIn	1967
gptkbp:firstFDAApproval	1992
gptkbp:IUPACName	(2aR,4S,4aS,6R,9S,11S,12aR,12bS)-11-acetoxy-12b-benzoyloxy-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyloxy]-4,6-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2,2a,3,4,4a,5,6,9,10,11,12,12a,12b-tetradecahydro-1H-7,11-methanocyclodeca[3,4]benz[1,2-b]oxet-9-yl benzoate
gptkbp:KEGGID	D05367
gptkbp:legalStatus	prescription only off-patent
gptkbp:mechanismOfAction	inhibits cell division stabilizes microtubules
gptkbp:metabolism	liver
gptkbp:molecularWeight	853.9 g/mol
gptkbp:origin	bark of Taxus brevifolia
gptkbp:pregnancyCategory	D (US)
gptkbp:producedBy	gptkb:Bristol-Myers_Squibb
gptkbp:PubChem_CID	gptkb:CHEMBL92 36314 DB01229
gptkbp:routeOfAdministration	intravenous
gptkbp:sideEffect	nausea hair loss neutropenia allergic reactions
gptkbp:solubility	insoluble in water
gptkbp:UNII	C376O5M5SL
gptkbp:usedFor	gptkb:cancer gptkb:Kaposi's_sarcoma
gptkbp:bfsParent	gptkb:Paclitaxel
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Taxol