Statements (32)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:enzyme
|
gptkbp:activatedBy |
gptkb:Ras
Rap small GTPases |
gptkbp:alternativeName |
gptkb:PLCE1
PLC-epsilon phosphoinositide phospholipase C-epsilon |
gptkbp:associatedWith |
esophageal cancer
nephrotic syndrome |
gptkbp:domain |
gptkb:PH_domain
gptkb:EF-hand_domain C2 domain CDC25 homology domain Ras-associating domain |
gptkbp:EC_number |
3.1.4.11
|
gptkbp:encodedBy |
gptkb:PLCE1_gene
|
gptkbp:foundIn |
gptkb:Homo_sapiens
|
gptkbp:function |
hydrolyzes phosphatidylinositol 4,5-bisphosphate
generates second messengers diacylglycerol and inositol trisphosphate |
gptkbp:gene |
gptkb:PLCE1
|
gptkbp:HGNC_ID |
9066
|
https://www.w3.org/2000/01/rdf-schema#label |
Phospholipase C epsilon
|
gptkbp:involves |
signal transduction
|
gptkbp:locatedOnChromosome |
10q23
|
gptkbp:molecularWeight |
~230 kDa
|
gptkbp:OMIM |
608414
|
gptkbp:RefSeq |
NM_016341
|
gptkbp:subcellularLocation |
gptkb:cytoplasm
gptkb:plasma_membrane |
gptkbp:UniProtID |
Q9P212
|
gptkbp:bfsParent |
gptkb:PLCε
|
gptkbp:bfsLayer |
7
|