PTEN induced putative kinase 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:PINK1 gptkb:BRPK gptkb:PARK6
gptkbp:associatedWith	autosomal recessive inheritance
gptkbp:discoveredBy	2001
gptkbp:encodedBy	gptkb:PINK1_gene
gptkbp:enzymeCommissionNumber	EC 2.7.11.1
gptkbp:expressedIn	gptkb:skeletal_muscle gptkb:testis brain heart
gptkbp:firstDescribed	gptkb:Nature_Genetics gptkb:Valente_et_al.
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	serine/threonine kinase activity mitochondrial quality control
gptkbp:gene	gptkb:PINK1
gptkbp:HGNC_ID	14581
gptkbp:involves	gptkb:Parkinson's_disease mitophagy
gptkbp:locatedOnChromosome	gptkb:1p36
gptkbp:molecularWeight	63 kDa
gptkbp:mutationAssociatedWith	gptkb:early-onset_Parkinson's_disease nonsense missense frameshift splice site
gptkbp:OMIM	608309
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Drosophila_melanogaster
gptkbp:pathway	autophagy cellular response to stress ubiquitin-proteasome system
gptkbp:phosphorylates	gptkb:Parkin ubiquitin
gptkbp:product	gptkb:PINK1_gene
gptkbp:RefSeq	gptkb:NP_115785.1
gptkbp:regulates	mitochondrial dynamics mitochondrial fission mitochondrial fusion
gptkbp:requires	Parkin recruitment to mitochondria
gptkbp:structure	contains kinase domain contains mitochondrial targeting sequence
gptkbp:subcellularLocation	mitochondrial outer membrane
gptkbp:UniProtID	gptkb:Q9BXM7
gptkbp:bfsParent	gptkb:PINK1_gene
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	PTEN induced putative kinase 1