PTEN induced putative kinase 1

URI: https://gptkb.org/entity/PTEN_induced_putative_kinase_1
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:PINK1
gptkb:BRPK
gptkb:PARK6
gptkbp:associatedWith autosomal recessive inheritance
gptkbp:discoveredBy 2001
gptkbp:encodedBy gptkb:PINK1_gene
gptkbp:enzymeCommissionNumber EC 2.7.11.1
gptkbp:expressedIn gptkb:skeletal_muscle
gptkb:testis
brain
heart
gptkbp:firstDescribed gptkb:Nature_Genetics
gptkb:Valente_et_al.
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function serine/threonine kinase activity
mitochondrial quality control
gptkbp:gene gptkb:PINK1
gptkbp:HGNC_ID 14581
https://www.w3.org/2000/01/rdf-schema#label PTEN induced putative kinase 1
gptkbp:involves gptkb:Parkinson's_disease
mitophagy
gptkbp:locatedOnChromosome gptkb:1p36
gptkbp:molecularWeight 63 kDa
gptkbp:mutationAssociatedWith gptkb:early-onset_Parkinson's_disease
nonsense
missense
frameshift
splice site
gptkbp:OMIM 608309
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkbp:pathway autophagy
cellular response to stress
ubiquitin-proteasome system
gptkbp:phosphorylates gptkb:Parkin
ubiquitin
gptkbp:product gptkb:PINK1_gene
gptkbp:RefSeq gptkb:NP_115785.1
gptkbp:regulates mitochondrial dynamics
mitochondrial fission
mitochondrial fusion
gptkbp:requires Parkin recruitment to mitochondria
gptkbp:structure contains kinase domain
contains mitochondrial targeting sequence
gptkbp:subcellularLocation mitochondrial outer membrane
gptkbp:UniProtID gptkb:Q9BXM7
gptkbp:bfsParent gptkb:PINK1_gene
gptkbp:bfsLayer 8