PTEN-induced putative kinase 1

URI: https://gptkb.org/entity/PTEN-induced_putative_kinase_1
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:PINK1
gptkbp:associatedWith gptkb:Parkinson's_disease
gptkbp:discoveredBy gptkb:Valente_et_al.
2001
gptkbp:encodedBy gptkb:PINK1_gene
gptkbp:Entrez_Gene_ID GC01M020282
gptkbp:enzymeCommissionNumber 2.7.11.1
gptkbp:expressedIn gptkb:skeletal_muscle
brain
heart
gptkbp:function serine/threonine kinase activity
mitochondrial quality control
gptkbp:gene gptkb:PINK1
gptkbp:HGNC_ID 14581
https://www.w3.org/2000/01/rdf-schema#label PTEN-induced putative kinase 1
gptkbp:involvedIn autophagy
cellular response to stress
mitochondrial fission
mitochondrial depolarization response
gptkbp:locale mitochondria
gptkbp:locatedOnChromosome gptkb:chromosome_1p36
gptkbp:molecularWeight 63 kDa
gptkbp:mutationAssociatedWith gptkb:early-onset_Parkinson's_disease
missense mutation
nonsense mutation
deletion mutation
gptkbp:OMIM 608309
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkbp:pathway mitophagy pathway
Parkin-ubiquitin pathway
gptkbp:PDB gptkb:6EQI
gptkbp:phosphorylates gptkb:Parkin
ubiquitin
gptkbp:product gptkb:PINK1_gene
gptkbp:RefSeq gptkb:NP_115785.1
gptkbp:regulates mitophagy
gptkbp:reviewedBy gptkb:UniProtKB/Swiss-Prot
gptkbp:significance autosomal recessive inheritance
gptkbp:structure contains kinase domain
contains mitochondrial targeting sequence
gptkbp:UniProtID gptkb:Q9BXM7
gptkbp:bfsParent gptkb:PINK1
gptkbp:bfsLayer 7