|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:autosomal_recessive_juvenile_Parkinson's_disease
|
|
gptkbp:discoveredBy
|
Japanese researchers
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:domain
|
gptkb:IBR_domain
RING finger domain
Ubiquitin-like domain
|
|
gptkbp:encodedBy
|
gptkb:PARK2_gene
|
|
gptkbp:Entrez_Gene_ID
|
5071
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:spinal_cord
gptkb:testis
brain
heart
liver
pancreas
peripheral blood leukocytes
|
|
gptkbp:function
|
E3 ubiquitin ligase
|
|
gptkbp:HGNC_ID
|
8607
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Parkin protein
|
|
gptkbp:interactsWith
|
gptkb:PINK1_protein
ubiquitin
mitochondrial proteins
|
|
gptkbp:involvedIn
|
ubiquitin-proteasome system
|
|
gptkbp:length
|
465 amino acids
|
|
gptkbp:locale
|
gptkb:cytoplasm
mitochondria
|
|
gptkbp:locatedOnChromosome
|
6q25.2-q27
|
|
gptkbp:molecularWeight
|
52 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Parkinson's_disease
missense mutation
nonsense mutation
frameshift mutation
deletion mutation
duplication mutation
|
|
gptkbp:OMIM
|
602544
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:5C1Z
4K95
4BM9
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
mitophagy
|
|
gptkbp:role
|
protein quality control
cellular stress response
neuroprotection
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
O60260
|
|
gptkbp:bfsParent
|
gptkb:PINK1_gene
|
|
gptkbp:bfsLayer
|
8
|