Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
histone |
| gptkbp:amendedBy |
phosphorylation
methylation ubiquitination acetylation |
| gptkbp:component |
nucleosome
|
| gptkbp:conservedIn |
eukaryotes
|
| gptkbp:discoveredIn |
late 19th century
|
| gptkbp:formsComplexWith |
gptkb:Histone_H4
Histone H2A Histone H2B |
| gptkbp:foundIn |
eukaryotic cell nucleus
|
| gptkbp:function |
chromatin structure
DNA packaging |
| gptkbp:gene |
HIST3H3
H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST2H3A HIST2H3C HIST2H3D |
| gptkbp:hasAminoAcidLength |
~135 amino acids
|
| gptkbp:hasC-terminalTail |
yes
|
| gptkbp:hasIsoform |
CENP-A
H3.1 H3.2 H3.3 |
| gptkbp:hasN-terminalTail |
yes
|
| https://www.w3.org/2000/01/rdf-schema#label |
Histone H3
|
| gptkbp:involvedIn |
cell cycle
epigenetic regulation gene expression regulation chromosome condensation |
| gptkbp:modificationSite |
lysine 27
lysine 4 lysine 9 serine 10 threonine 3 |
| gptkbp:molecularWeight |
~15 kDa
|
| gptkbp:mutationAssociatedWith |
pediatric glioma
G34R G34V K27M chondroblastoma |
| gptkbp:PDB |
1KX5
|
| gptkbp:subject |
histone modification
|
| gptkbp:subjectOf |
cancer research
histone code hypothesis |
| gptkbp:UniProtID |
P84243
|
| gptkbp:bfsParent |
gptkb:MSK1
|
| gptkbp:bfsLayer |
7
|