Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:alternativeName |
gptkb:p110α
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform gptkb:PIK3CA_protein |
| gptkbp:catalyzes |
phosphorylation of phosphatidylinositol-4,5-bisphosphate
|
| gptkbp:encodedBy |
gptkb:PIK3CA_gene
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| https://www.w3.org/2000/01/rdf-schema#label |
PI3K-alpha
|
| gptkbp:involvedIn |
gptkb:PI3K/AKT_signaling_pathway
cell proliferation cell survival metabolism cell growth |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:endometrial_cancer colorectal cancer |
| gptkbp:produces |
phosphatidylinositol-3,4,5-trisphosphate
|
| gptkbp:subunit |
gptkb:p110-alpha
gptkb:protein p85 regulatory subunit |
| gptkbp:target |
gptkb:alpelisib
PI3K inhibitors |
| gptkbp:bfsParent |
gptkb:copanlisib
|
| gptkbp:bfsLayer |
5
|