|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD279
|
|
gptkbp:associatedWith
|
gptkb:non-small_cell_lung_cancer
colorectal cancer
melanoma
Hodgkin lymphoma
rheumatoid arthritis
renal cell carcinoma
autoimmune diabetes
|
|
gptkbp:discoveredBy
|
gptkb:Tasuku_Honjo
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
IgV-like domain
|
|
gptkbp:encodedBy
|
gptkb:PDCD1_gene
|
|
gptkbp:expressedIn
|
gptkb:B_cells
gptkb:T_cells
dendritic cells
monocytes
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:fullName
|
gptkb:Programmed_cell_death_protein_1
|
|
gptkbp:function
|
immunotherapy
inhibits T cell activity
|
|
gptkbp:gene
|
PDCD1
|
|
gptkbp:HGNC_ID
|
8765
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PD1
|
|
gptkbp:involvedIn
|
autoimmune diseases
chronic infections
tumor immune evasion
|
|
gptkbp:ligand
|
gptkb:PD-L2
PD-L1
|
|
gptkbp:locatedOnChromosome
|
gptkb:2q37.3_(human)
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~55 kDa
|
|
gptkbp:motif
|
gptkb:ITIM
ITSM
|
|
gptkbp:OMIM
|
600244
|
|
gptkbp:PDB
|
3RRQ
|
|
gptkbp:regulates
|
T cell exhaustion
peripheral tolerance
immune homeostasis
|
|
gptkbp:role
|
immunotherapy
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
gptkb:durvalumab
gptkb:atezolizumab
gptkb:camrelizumab
gptkb:sintilimab
gptkb:tislelizumab
gptkb:toripalimab
gptkb:pembrolizumab
gptkb:cemiplimab
gptkb:nivolumab
gptkb:avelumab
|
|
gptkbp:UniProtID
|
Q15116
|
|
gptkbp:bfsParent
|
gptkb:programmed_cell_death_protein_1_(PD-1)
|
|
gptkbp:bfsLayer
|
6
|