|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:urokinase
urokinase plasminogen activator
|
|
gptkbp:cleavage
|
plasmin
|
|
gptkbp:discoveredBy
|
Morten P. Schousboe
|
|
gptkbp:EC_number
|
3.4.21.73
|
|
gptkbp:expressedIn
|
gptkb:kidney
macrophages
endothelial cells
tumor cells
|
|
gptkbp:formsComplexWith
|
gptkb:PAI-1
PAI-2
uPAR
|
|
gptkbp:fullName
|
gptkb:urokinase-type_plasminogen_activator
|
|
gptkbp:function
|
gptkb:serine_protease
converts plasminogen to plasmin
|
|
gptkbp:gene
|
gptkb:PLAU
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
uPA
|
|
gptkbp:inhibitedBy
|
gptkb:PAI-1
PAI-2
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q22.2
|
|
gptkbp:medicalUse
|
treatment of deep vein thrombosis
treatment of pulmonary embolism
treatment of myocardial infarction
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
poor prognosis in breast cancer
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1C5W
1F5L
1OWE
|
|
gptkbp:recipient
|
uPAR
|
|
gptkbp:regulates
|
wound healing
angiogenesis
inflammation
cell adhesion
|
|
gptkbp:role
|
cell migration
metastasis
fibrinolysis
tissue remodeling
tumor invasion
extracellular matrix degradation
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains serine protease domain
contains kringle domain
|
|
gptkbp:UniProtID
|
gptkb:P00749
|
|
gptkbp:usedAs
|
gptkb:tissue_plasminogen_activator
biomarker in cancer
|
|
gptkbp:bfsParent
|
gptkb:EC_3.4.21.26
gptkb:PLAU
|
|
gptkbp:bfsLayer
|
7
|