|
gptkbp:instanceOf
|
UniProt accession number
|
|
gptkbp:alternativeName
|
gptkb:GSK3B
gptkb:GSK-3_beta
GSK3-beta
|
|
gptkbp:containsGene
|
gptkb:GSK3B
|
|
gptkbp:database
|
gptkb:UniProt
|
|
gptkbp:EC_number
|
2.7.11.26
|
|
gptkbp:Entrez_Gene_ID
|
2932
ENSG00000082701
|
|
gptkbp:enzyme
|
true
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
Serine/threonine-protein kinase activity
|
|
gptkbp:hasGeneCardsID
|
gptkb:GSK3B
|
|
gptkbp:hasIsoform
|
Isoform 1
Isoform 2
|
|
gptkbp:hasPfam
|
PF0069
|
|
gptkbp:hasPhosphorylationSite
|
Ser9
Tyr216
|
|
gptkbp:hasProteinName
|
gptkb:Glycogen_synthase_kinase-3_beta
|
|
gptkbp:hasRefSeqID
|
NP_002084.2
|
|
gptkbp:hasSequenceStatus
|
Reviewed
|
|
gptkbp:hasUniGeneID
|
Hs.654
|
|
gptkbp:hasUniProtEntryName
|
GSK3B_HUMAN
|
|
gptkbp:HGNC_ID
|
4617
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P49810
|
|
gptkbp:InterPro
|
gptkb:IPR000719
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
gptkb:Insulin_signaling_pathway
|
|
gptkbp:isAssociatedWithDisease
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:Diabetes_mellitus
gptkb:Bipolar_disorder
|
|
gptkbp:isKinase
|
true
|
|
gptkbp:length
|
420 amino acids
|
|
gptkbp:locatedOnChromosome
|
3q13.33
|
|
gptkbp:molecularWeight
|
46,744 Da
|
|
gptkbp:OMIM
|
605004
|
|
gptkbp:organism
|
gptkb:human
|
|
gptkbp:pathway
|
KEGG:hsa04151 (PI3K-Akt signaling pathway)
KEGG:hsa04310 (Wnt signaling pathway)
KEGG:hsa04910 (Insulin signaling pathway)
|
|
gptkbp:PDB
|
gptkb:1Q4L
gptkb:6Y9S
4ACD
|
|
gptkbp:proteinFamily
|
Serine/threonine-protein kinase family
|
|
gptkbp:Reactome
|
R-HSA-195258
R-HSA-202424
R-HSA-450294
|
|
gptkbp:refersTo
|
gptkb:Glycogen_synthase_kinase-3_beta
|
|
gptkbp:subcellularLocation
|
gptkb:Nucleus
gptkb:Cell_membrane
gptkb:Cytoplasm
|
|
gptkbp:targetOfDrug
|
true
|
|
gptkbp:bfsParent
|
gptkb:PSEN2
gptkb:presenilin-2
|
|
gptkbp:bfsLayer
|
8
|