Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:Nef_protein
gptkb:Negative_regulatory_factor |
| gptkbp:function |
modulates host cell signaling
downregulates CD4 and MHC-I enhances viral infectivity |
| gptkbp:gene |
nef
|
| https://www.w3.org/2000/01/rdf-schema#label |
P12497 (HIV-1 Nef)
|
| gptkbp:interactsWith |
gptkb:AP-2_complex
gptkb:Src_family_kinases gptkb:CD4 gptkb:MHC-I |
| gptkbp:length |
206 amino acids
|
| gptkbp:molecularWeight |
23 kDa
|
| gptkbp:organism |
gptkb:Human_immunodeficiency_virus_type_1_(HIV-1)
|
| gptkbp:pathway |
HIV-1 infection
|
| gptkbp:postTranslationalModification |
myristoylation
|
| gptkbp:sequence_database |
gptkb:NCBI
gptkb:PDB gptkb:UniProt |
| gptkbp:sequenceStatus |
complete
|
| gptkbp:structure |
contains SH3-binding domain
|
| gptkbp:subcellularLocation |
gptkb:cytoplasm
membrane-associated |
| gptkbp:taxonomic_identifier |
11676
|
| gptkbp:UniProtID |
P12497
|
| gptkbp:bfsParent |
gptkb:Nef_(protein)
|
| gptkbp:bfsLayer |
7
|