Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:Nef
|
| gptkbp:discoveredIn |
1986
|
| gptkbp:encodedBy |
gptkb:nef_gene
|
| gptkbp:foundIn |
gptkb:HIV-1
gptkb:HIV-2 |
| gptkbp:function |
enhances viral infectivity
modulates T cell activation downregulates CD4 and MHC I on host cell surface |
| https://www.w3.org/2000/01/rdf-schema#label |
Negative regulatory factor
|
| gptkbp:interactsWith |
gptkb:PI3K
gptkb:AP-2_complex gptkb:Src_family_kinases |
| gptkbp:locale |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:molecularWeight |
27-35 kDa
|
| gptkbp:role |
immune evasion
HIV pathogenesis viral replication efficiency |
| gptkbp:structure |
contains SH3-binding domain
contains myristoylation site |
| gptkbp:bfsParent |
gptkb:P12497_(HIV-1_Nef)
|
| gptkbp:bfsLayer |
8
|