|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:antigenPresentation
|
endogenous peptides
|
|
gptkbp:antigenSource
|
cytosolic proteins
|
|
gptkbp:component
|
gptkb:beta-2_microglobulin
alpha chain
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Dausset
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:downregulatedIn
|
tumor cells
some viruses
|
|
gptkbp:encodedBy
|
MHC gene cluster
|
|
gptkbp:foundIn
|
all nucleated cells of jawed vertebrates
|
|
gptkbp:fullName
|
Major Histocompatibility Complex class I
|
|
gptkbp:function
|
presentation of peptide antigens to cytotoxic T cells
|
|
gptkbp:hasPolymorphism
|
highly polymorphic
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MHC-I
|
|
gptkbp:humanGenes
|
gptkb:HLA-A
gptkb:HLA-B
gptkb:HLA-C
|
|
gptkbp:involvedIn
|
autoimmunity
immune surveillance
transplant rejection
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6_(human)
gptkb:chromosome_17_(mouse)
|
|
gptkbp:mouseGenes
|
gptkb:H-2D
gptkb:H-2K
gptkb:H-2L
|
|
gptkbp:peptideBinding
|
binds peptides 8-10 amino acids long
|
|
gptkbp:recognizedBy
|
gptkb:T_cell_receptor_(TCR)
gptkb:CD8+_T_cells
natural killer (NK) cells (absence or alteration)
|
|
gptkbp:regulates
|
gptkb:virus
cytokines
interferons
|
|
gptkbp:relatedTo
|
MHC-II
MHC-III
|
|
gptkbp:role
|
adaptive immune response
|
|
gptkbp:significance
|
organ transplantation
immunotherapy
disease association
|
|
gptkbp:species
|
humans
mice
other jawed vertebrates
|
|
gptkbp:structure
|
heterodimer of alpha chain and beta-2 microglobulin
|
|
gptkbp:usedIn
|
diagnostics
immunological research
|
|
gptkbp:bfsParent
|
gptkb:P12497_(HIV-1_Nef)
|
|
gptkbp:bfsLayer
|
8
|