|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:encodedBy
|
gptkb:nef_gene
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:foundIn
|
gptkb:HIV-1
gptkb:HIV-2
|
|
gptkbp:function
|
downregulation of CD4
downregulation of MHC I
enhancement of viral infectivity
modulation of T cell activation
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:AP-2_complex
gptkb:Src_family_kinases
|
|
gptkbp:length
|
206 amino acids (HIV-1)
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:HIV-1_genome
|
|
gptkbp:molecularWeight
|
27-35 kDa
|
|
gptkbp:nameOrigin
|
Negative factor
|
|
gptkbp:notEssentialFor
|
viral replication in vitro
|
|
gptkbp:postTranslationalModification
|
myristoylation
|
|
gptkbp:requires
|
high viral load in vivo
|
|
gptkbp:roleInPathogenesis
|
immune evasion
AIDS progression
|
|
gptkbp:structure
|
contains SH3-binding domain
contains dileucine motif
contains polyproline region
|
|
gptkbp:bfsParent
|
gptkb:4932_(HIV-1_nef_gene)
gptkb:P12497_(HIV-1_Nef)
gptkb:nef_gene
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nef protein
|