Human immunodeficiency virus type 1 (HIV-1)

URI: https://gptkb.org/entity/Human_immunodeficiency_virus_type_1_(HIV-1)

GPTKB entity

Statements (62)

Predicate	Object
gptkbp:instanceOf	gptkb:virus
gptkbp:affects	immune system
gptkbp:antiretroviralTarget	gptkb:integrase gptkb:protease reverse transcriptase entry protein gp120 fusion protein gp41
gptkbp:biosafetyLevel	3
gptkbp:cause	acquired immunodeficiency syndrome (AIDS)
gptkbp:coReceptor	gptkb:CCR5 gptkb:CXCR4
gptkbp:discoveredBy	gptkb:Luc_Montagnier gptkb:Françoise_Barré-Sinoussi
gptkbp:discoveredIn	1983
gptkbp:entryReceptor	gptkb:CD4
gptkbp:enveloped	true
gptkbp:family	gptkb:Retroviridae
gptkbp:firstIsolatedFrom	patient with lymphadenopathy
gptkbp:genomeSize	~9.7 kb
gptkbp:genomeType	single-stranded RNA
gptkbp:genus	gptkb:Lentivirus
gptkbp:hostedBy	gptkb:human
https://www.w3.org/2000/01/rdf-schema#label	Human immunodeficiency virus type 1 (HIV-1)
gptkbp:NCBITaxonID	11676
gptkbp:notable_for	env tat pol gag rev nef vif vpr vpu
gptkbp:notableFor	gptkb:gp120 gptkb:gp41 gptkb:integrase gptkb:protease reverse transcriptase p24
gptkbp:numberOfGenes	9
gptkbp:origin	cross-species transmission from chimpanzees
gptkbp:pandemic	true
gptkbp:primaryTargetCell	gptkb:dendritic_cell gptkb:CD4+_T_cell macrophage
gptkbp:relatedTo	Human immunodeficiency virus type 2 (HIV-2)
gptkbp:replicationSite	host cell nucleus host cell cytoplasm
gptkbp:subspecies	gptkb:HIV-1_group_M gptkb:HIV-1_group_N gptkb:HIV-1_group_O gptkb:HIV-1_group_P
gptkbp:taxonRank	gptkb:species 11709
gptkbp:transmissionRoute	sharing needles blood transfusion mother-to-child sexual contact
gptkbp:treatment	antiretroviral therapy (ART)
gptkbp:vaccineStatus	no licensed vaccine
gptkbp:bfsParent	gptkb:P12497_(HIV-1_Nef)
gptkbp:bfsLayer	8