|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:MDR1
P-glycoprotein gene
|
|
gptkbp:associatedWith
|
gptkb:cancer
epilepsy
pharmacogenomics
drug distribution
inflammatory bowel disease
chemotherapy resistance
drug toxicity
drug absorption
drug excretion
HIV treatment response
|
|
gptkbp:biologicalProcess
|
protection against xenobiotics
transmembrane transporter activity
ATP-dependent drug efflux pump
|
|
gptkbp:discoveredBy
|
gptkb:Victor_Ling
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodes
|
gptkb:P-glycoprotein
|
|
gptkbp:Entrez_Gene_ID
|
5243
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:placenta
gptkb:blood-brain_barrier
liver
intestine
|
|
gptkbp:hasPolymorphism
|
C1236T
C3435T
G2677T/A
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:40
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABCB1 gene
|
|
gptkbp:involvedIn
|
multidrug resistance
xenobiotic transport
drug efflux
|
|
gptkbp:length
|
209,857 bp
|
|
gptkbp:locatedOnChromosome
|
7q21.12
|
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_(ABC)_transporter_family
|
|
gptkbp:numberOfExons
|
29
|
|
gptkbp:OMIM
|
171050
|
|
gptkbp:orthologInMouse
|
Abcb1a
Abcb1b
|
|
gptkbp:product
|
12 transmembrane domains
P-glycoprotein (ABCB1)
2 nucleotide-binding domains
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
bioavailability of drugs
blood-brain barrier permeability
cellular efflux of drugs
|
|
gptkbp:UniProtID
|
P08183
|
|
gptkbp:bfsParent
|
gptkb:ABCB1_gene_mutation
gptkb:Multidrug_resistance_protein_1
|
|
gptkbp:bfsLayer
|
7
|