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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:alternativeName
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gptkb:NOS
gptkb:NO_synthase
gptkb:nitrogen_monoxide_synthase
|
|
gptkbp:associatedWith
|
hypertension
neurodegenerative diseases
septic shock
|
|
gptkbp:catalyzes
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production of nitric oxide from L-arginine
|
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gptkbp:cofactor
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gptkb:FMN
gptkb:FAD
gptkb:tetrahydrobiopterin
hemoglobin
NADPH
|
|
gptkbp:discoveredBy
|
gptkb:Salvatore_Moncada
|
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gptkbp:EC_number
|
1.14.13.39
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
|
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gptkbp:gene
|
gptkb:NOS
|
|
gptkbp:hasIsoform
|
gptkb:endothelial_nitric_oxide_synthase
gptkb:inducible_nitric_oxide_synthase
gptkb:neuronal_nitric_oxide_synthase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nitric oxide synthase
|
|
gptkbp:inhibitedBy
|
gptkb:L-NAME
gptkb:aminoguanidine
|
|
gptkbp:involves
|
immune response
neurotransmission
vasodilation
|
|
gptkbp:locatedIn
|
gptkb:cytoplasm
cell membrane (for some isoforms)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12_(NOS1)
gptkb:chromosome_17_(NOS2)
gptkb:chromosome_7_(NOS3)
|
|
gptkbp:molecularWeight
|
about 130-160 kDa (varies by isoform)
|
|
gptkbp:product
|
citrulline
nitric oxide
|
|
gptkbp:regulates
|
phosphorylation
calcium/calmodulin
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:L-arginine
|
|
gptkbp:UniProtID
|
P29473 (for human NOS3)
P29474 (for human NOS1)
P29475 (for human NOS2)
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|