inducible nitric oxide synthase

URI: https://gptkb.org/entity/inducible_nitric_oxide_synthase
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation iNOS
gptkbp:alternativeName NOS2
calcium-independent NOS
macrophage NOS
type II nitric oxide synthase
gptkbp:catalyzes production of nitric oxide from L-arginine
gptkbp:cofactor gptkb:FMN
gptkb:FAD
gptkb:tetrahydrobiopterin
hemoglobin
NADPH
gptkbp:discoveredBy 1990s
gptkbp:EC_number 1.14.13.39
gptkbp:Entrez_Gene_ID 4843
gptkbp:expressed_in_response_to inflammatory stimuli
gptkbp:expressedIn gptkb:hepatocytes
macrophages
endothelial cells
smooth muscle cells
gptkbp:foundIn mammals
gptkbp:gene NOS2
https://www.w3.org/2000/01/rdf-schema#label inducible nitric oxide synthase
gptkbp:inhibitedBy gptkb:aminoguanidine
L-NIL
gptkbp:locatedOnChromosome gptkb:17q11.2
gptkbp:molecularWeight about 130 kDa
gptkbp:orthologInMouse Nos2
gptkbp:overexpressedIn gptkb:cancer
asthma
neurodegenerative diseases
autoimmune diseases
septic shock
gptkbp:product nitric oxide
L-citrulline
gptkbp:regulates gptkb:lipopolysaccharide_(LPS)
cytokines
gptkbp:requires oxygen
NADPH
gptkbp:role inflammation
immune response
host defense
gptkbp:structure homodimer
gptkbp:subcellularLocation gptkb:cytoplasm
gptkbp:substrate gptkb:L-arginine
gptkbp:UniProtID P35228
gptkbp:bfsParent gptkb:Nitric_oxide_synthase
gptkbp:bfsLayer 7