neuronal nitric oxide synthase

URI: https://gptkb.org/entity/neuronal_nitric_oxide_synthase
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs nNOS
gptkbp:alternativeSplicing yes
gptkbp:associatedWith neurodegenerative diseases
psychiatric disorders
gptkbp:catalyzes production of nitric oxide from L-arginine
gptkbp:cofactor gptkb:FMN
gptkb:FAD
gptkb:tetrahydrobiopterin
hemoglobin
NADPH
gptkbp:discoveredBy gptkb:Solomon_H._Snyder
gptkbp:discoveredIn 1991
gptkbp:EC_number 1.14.13.39
gptkbp:expressedIn central nervous system
peripheral nervous system
gptkbp:foundIn gptkb:skeletal_muscle
neurons
gptkbp:function gptkb:synaptic_plasticity
neurotransmission
regulation of blood flow
gptkbp:gene NOS1
https://www.w3.org/2000/01/rdf-schema#label neuronal nitric oxide synthase
gptkbp:inhibitedBy gptkb:L-NAME
7-nitroindazole
gptkbp:interactsWith gptkb:PSD-95
CAPON
alpha-syntrophin
gptkbp:locatedOnChromosome 12q24.22
gptkbp:molecularWeight ~160 kDa
gptkbp:mutationAssociatedWith gptkb:autism_spectrum_disorder
epilepsy
schizophrenia
gptkbp:OMIM 163731
gptkbp:orthologIn NOS1
gptkbp:orthologInMouse Nos1
gptkbp:PDB 1OM4
gptkbp:phosphorylates Ser1412
Ser847
gptkbp:regulates calmodulin-dependent
gptkbp:structure homodimer
gptkbp:subcellularLocation gptkb:cell_membrane
gptkb:cytoplasm
postsynaptic density
gptkbp:UniProtID P29475
gptkbp:bfsParent gptkb:Nitric_oxide_synthase
gptkbp:bfsLayer 7