|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:E3_ubiquitin-protein_ligase_NEDD4
RPF1
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:discoveredBy
|
1992
|
|
gptkbp:domain
|
gptkb:WW_domain
gptkb:HECT_domain
C2 domain
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.3.2.27
|
|
gptkbp:fullName
|
Neural precursor cell expressed developmentally down-regulated protein 4
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
ubiquitin-mediated protein degradation
|
|
gptkbp:gene
|
gptkb:NEDD4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nedd4 protein
|
|
gptkbp:locatedOnChromosome
|
chromosome 15q21.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Nedd4
rat Nedd4
|
|
gptkbp:pathway
|
endocytosis
protein ubiquitination
|
|
gptkbp:regulates
|
phosphorylation
autoubiquitination
|
|
gptkbp:substrate
|
gptkb:PTEN
ENaC (epithelial sodium channel)
IGF-IR
|
|
gptkbp:UniProtID
|
P46934
|
|
gptkbp:bfsParent
|
gptkb:WW_domain
|
|
gptkbp:bfsLayer
|
7
|