Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic alteration
|
| gptkbp:associatedWith |
gptkb:cancer
solid tumors |
| gptkbp:cause |
oncogenic signaling
|
| gptkbp:detects |
gptkb:FISH
next-generation sequencing immunohistochemistry |
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
gptkb:neuroblastoma
gptkb:Wilms_tumor gptkb:biliary_tract_cancer gptkb:cancer gptkb:medulloblastoma gptkb:endometrial_cancer gptkb:rhabdomyosarcoma gptkb:retinoblastoma gptkb:Ewing_sarcoma gptkb:secretory_breast_carcinoma gptkb:infantile_fibrosarcoma colorectal cancer esophageal cancer liver cancer melanoma pancreatic cancer prostate cancer testicular cancer bladder cancer cholangiocarcinoma head and neck cancer osteosarcoma gastric cancer appendiceal cancer glioma renal cell carcinoma malignant peripheral nerve sheath tumor adult leukemia pediatric leukemia gastrointestinal stromal tumors salivary gland tumors pediatric glioma adult glioma adult sarcoma adult thyroid cancer pediatric sarcoma pediatric thyroid cancer spitzoid tumors |
| https://www.w3.org/2000/01/rdf-schema#label |
NTRK gene fusion
|
| gptkbp:involvedIn |
gptkb:NTRK1
gptkb:NTRK2 gptkb:NTRK3 |
| gptkbp:mechanismOfAction |
chromosomal rearrangement
|
| gptkbp:occurredIn |
pediatric cancers
adult cancers |
| gptkbp:prevalence |
rare
|
| gptkbp:result |
constitutive TRK kinase activation
|
| gptkbp:target |
gptkb:entrectinib
gptkb:larotrectinib |
| gptkbp:bfsParent |
gptkb:Vitrakvi
|
| gptkbp:bfsLayer |
8
|