|
gptkbp:instanceOf
|
gptkb:genetic_alteration
|
|
gptkbp:associatedWith
|
gptkb:cancer
solid tumors
|
|
gptkbp:cause
|
oncogenic signaling
|
|
gptkbp:detects
|
gptkb:FISH
next-generation sequencing
immunohistochemistry
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:foundIn
|
gptkb:neuroblastoma
gptkb:Wilms_tumor
gptkb:biliary_tract_cancer
gptkb:cancer
gptkb:medulloblastoma
gptkb:renal_cell_carcinoma
gptkb:bladder_cancer
gptkb:endometrial_cancer
gptkb:rhabdomyosarcoma
gptkb:retinoblastoma
gptkb:Ewing_sarcoma
gptkb:secretory_breast_carcinoma
gptkb:glioma
gptkb:testicular_cancer
gptkb:infantile_fibrosarcoma
gptkb:melanoma
colorectal cancer
esophageal cancer
liver cancer
pancreatic cancer
prostate cancer
cholangiocarcinoma
head and neck cancer
osteosarcoma
gastric cancer
appendiceal cancer
malignant peripheral nerve sheath tumor
adult leukemia
pediatric leukemia
gastrointestinal stromal tumors
salivary gland tumors
pediatric glioma
adult glioma
adult sarcoma
adult thyroid cancer
pediatric sarcoma
pediatric thyroid cancer
spitzoid tumors
|
|
gptkbp:involvedIn
|
gptkb:NTRK1
gptkb:NTRK2
gptkb:NTRK3
|
|
gptkbp:mechanismOfAction
|
gptkb:chromosomal_rearrangement
|
|
gptkbp:occurredIn
|
pediatric cancers
adult cancers
|
|
gptkbp:prevalence
|
rare
|
|
gptkbp:result
|
constitutive TRK kinase activation
|
|
gptkbp:target
|
gptkb:entrectinib
gptkb:larotrectinib
|
|
gptkbp:bfsParent
|
gptkb:Vitrakvi
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTRK gene fusion
|