|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:tumor_protein_p53
p53 isoform 1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
|
|
gptkbp:biologicalProcess
|
apoptosis
DNA repair
senescence
cell cycle arrest
genomic stability
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:conservedIn
|
gptkb:p53_family
|
|
gptkbp:domain
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:encodedBy
|
gptkb:TP53
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:function
|
tumor suppressor
transcription factor
DNA-binding transcription factor activity
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:GOProcess
|
regulation of apoptosis
regulation of cell cycle
|
|
gptkbp:hasIsoform
|
P04637
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NP 000375.2
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
43.7 kDa
|
|
gptkbp:mutationAssociatedWith
|
loss of function leads to tumorigenesis
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
9606
|
|
gptkbp:orthologIn
|
gptkb:mouse_Trp53
gptkb:rat_Tp53
|
|
gptkbp:pathway
|
p53 signaling pathway
cell cycle pathway
|
|
gptkbp:PDB
|
gptkb:2OCJ
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:protein_name
|
cellular tumor antigen p53 isoform 1
|
|
gptkbp:RefSeq
|
gptkb:NP_000375.2
NM_000546.6
|
|
gptkbp:sequenceStatus
|
reviewed
|
|
gptkbp:structure
|
contains alpha helices and beta sheets
|
|
gptkbp:UniProtID
|
P04637-1
|
|
gptkbp:bfsParent
|
gptkb:apolipoprotein_B-100
|
|
gptkbp:bfsLayer
|
7
|