|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:NPM1
B23
numatrin
|
|
gptkbp:biologicalProcess
|
cell cycle regulation
genomic stability
ribosome assembly
|
|
gptkbp:discoveredBy
|
S. Chan
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:NPM1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:NPM1
ENSG00000181163
|
|
gptkbp:foundIn
|
nucleolus
|
|
gptkbp:function
|
ribosome biogenesis
molecular chaperone
regulation of ARF tumor suppressor
regulation of centrosome duplication
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nucleophosmin
|
|
gptkbp:interactsWith
|
gptkb:ARF
gptkb:p53
gptkb:nucleolin
HDM2
|
|
gptkbp:length
|
294 amino acids
|
|
gptkbp:locale
|
nucleolus
nucleoplasm
|
|
gptkbp:locatedOnChromosome
|
chromosome 5q35
|
|
gptkbp:molecularWeight
|
~37 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:acute_myeloid_leukemia
frameshift mutation
insertion mutation
|
|
gptkbp:OMIM
|
164040
|
|
gptkbp:PDB
|
2P1B
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
|
|
gptkbp:proteinFamily
|
nucleophosmin/nucleoplasmin family
|
|
gptkbp:RefSeq
|
NM_002520
|
|
gptkbp:role
|
cell proliferation
DNA repair
apoptosis regulation
stress response
chromatin remodeling
|
|
gptkbp:roleInCancer
|
tumor suppressor
oncoprotein
|
|
gptkbp:significance
|
prognostic marker in AML
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
oligomeric
|
|
gptkbp:subcellularLocation
|
shuttles between nucleus and cytoplasm
|
|
gptkbp:UniProtID
|
P06748
|
|
gptkbp:bfsParent
|
gptkb:NPM1
|
|
gptkbp:bfsLayer
|
6
|