Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alias |
gptkb:RTP
CAP43 DRG-1 PROXY1 TDD5 |
| gptkbp:associatedWith |
Charcot-Marie-Tooth disease type 4D
|
| gptkbp:discoveredIn |
1999
|
| gptkbp:Entrez_Gene_ID |
10397
ENSG00000104419 |
| gptkbp:expressedIn |
ubiquitous
high in kidney high in placenta high in prostate |
| gptkbp:fullName |
N-myc downstream-regulated gene 1
|
| gptkbp:function |
cell differentiation
tumor suppression stress response |
| gptkbp:gene |
gptkb:NDRG1
|
| gptkbp:geneType |
protein-coding
|
| gptkbp:GO_term |
GO:0008285 (negative regulation of cell proliferation)
GO:0006979 (response to oxidative stress) GO:0045596 (negative regulation of cell differentiation) |
| gptkbp:HGNC_ID |
HGNC:7679
|
| https://www.w3.org/2000/01/rdf-schema#label |
NDRG1
|
| gptkbp:interactsWith |
gptkb:SGK1
gptkb:p53 gptkb:beta-catenin gptkb:E-cadherin N-myc |
| gptkbp:length |
394 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:8q24.22
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
43 kDa
|
| gptkbp:mutationAssociatedWith |
causes hereditary motor and sensory neuropathy-Lom
|
| gptkbp:OMIM |
605262
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
mouse Ndrg1
rat Ndrg1 |
| gptkbp:pathway |
myelination
cellular response to stress |
| gptkbp:PDB |
2QMQ
|
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation |
| gptkbp:regulates |
upregulated by hypoxia
upregulated by p53 downregulated by N-myc |
| gptkbp:UniProtID |
Q92597
|
| gptkbp:bfsParent |
gptkb:Charcot-Marie-Tooth_disease
|
| gptkbp:bfsLayer |
6
|