Mitogen-activated protein kinase kinase kinase 12

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_kinase_kinase_12
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:DLK
gptkb:Dual_leucine_zipper-bearing_kinase
gptkbp:associatedWith neurodegenerative diseases
gptkbp:biologicalProcess signal transduction
neuronal apoptosis
protein kinase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:discoveredBy 1996
gptkbp:Entrez_Gene_ID 7786
GC12M070282
gptkbp:enzymeCommissionNumber 2.7.11.25
gptkbp:expressedIn gptkb:testis
brain
heart
gptkbp:function gptkb:MAPK_signaling_pathway
serine/threonine protein kinase activity
gptkbp:gene gptkb:MAP3K12
gptkbp:HGNC_ID 6862
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase kinase kinase 12
gptkbp:interactsWith gptkb:14-3-3_proteins
gptkb:JIP1
JIP2
JIP3
JIP4
gptkbp:length 1030
gptkbp:locatedOnChromosome 12q13.12
gptkbp:molecularWeight 114 kDa
gptkbp:OMIM 604687
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Map3k12
gptkbp:PDB gptkb:2Y9Q
gptkbp:phosphorylates gptkb:MAP2K4
gptkb:MAP2K7
gptkbp:postTranslationalModification phosphorylation
sumoylation
ubiquitination
gptkbp:RefSeq NM_006302
gptkbp:regulates apoptosis
neuronal development
axon growth
gptkbp:structure contains kinase domain
contains dual leucine zipper motif
gptkbp:UniProtID Q12852
gptkbp:bfsParent gptkb:MAP3K12
gptkb:Map3k12
gptkbp:bfsLayer 8