Macrophage Migration Inhibitory Factor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:MIF
gptkbp:alternativeName	gptkb:GIF gptkb:L-dopachrome_isomerase gptkb:phenylpyruvate_tautomerase glycosylation-inhibiting factor
gptkbp:associatedWith	gptkb:cancer sepsis autoimmune diseases rheumatoid arthritis
gptkbp:discoveredBy	gptkb:John_David
gptkbp:discoveredIn	1966
gptkbp:enzymeCommissionNumber	gptkb:EC_5.3.2.1
gptkbp:expressedIn	gptkb:pituitary_gland gptkb:T_cells various tissues macrophages
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	cytokine regulation of immune response inhibition of macrophage migration pro-inflammatory mediator
gptkbp:gene	gptkb:MIF_gene gptkb:MIF
gptkbp:GO_term	gptkb:GO:0006955_(immune_response) GO:0005125 (cytokine activity)
https://www.w3.org/2000/01/rdf-schema#label	Macrophage Migration Inhibitory Factor
gptkbp:inhibitedBy	random migration of macrophages
gptkbp:involves	inflammation immune system regulation
gptkbp:locatedOnChromosome	gptkb:22q11.23_(human)
gptkbp:molecularWeight	12.5 kDa
gptkbp:OMIM	153620
gptkbp:PDB	1MFI
gptkbp:promotion	production of IFN-gamma production of IL-1beta production of IL-6 production of TNF-alpha
gptkbp:recipient	gptkb:CD74 gptkb:CXCR2 gptkb:CXCR4 gptkb:CXCR7
gptkbp:RefSeq	NP_002406.1
gptkbp:regulates	apoptosis cell proliferation glucocorticoid action
gptkbp:structure	homotrimer
gptkbp:UniProtID	P14174
gptkbp:bfsParent	gptkb:MIF
gptkbp:bfsLayer	7