|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
autoimmune diseases
|
|
gptkbp:binds
|
peptide antigens
|
|
gptkbp:deficiencyCauses
|
immunodeficiency
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
MHC gene complex
|
|
gptkbp:expressedIn
|
gptkb:B_cells
dendritic cells
macrophages
antigen-presenting cells
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:fullName
|
Major Histocompatibility Complex class II
|
|
gptkbp:function
|
antigen presentation
|
|
gptkbp:gene
|
gptkb:HLA-DP
gptkb:HLA-DQ
gptkb:HLA-DR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MHC II
|
|
gptkbp:involvedIn
|
immune tolerance
transplant rejection
|
|
gptkbp:location
|
cell surface
|
|
gptkbp:mouseGene
|
I-A
I-E
|
|
gptkbp:peptideLength
|
13-25 amino acids
|
|
gptkbp:presentIn
|
gptkb:tonsils
gptkb:thymus
lymph nodes
spleen
lymphoid tissues
mucosal tissues
|
|
gptkbp:recognizedBy
|
gptkb:CD4+_T_cells
|
|
gptkbp:regulates
|
gptkb:interferon_gamma
gptkb:CIITA
|
|
gptkbp:role
|
gptkb:allergy
gptkb:graft-versus-host_disease
autoimmunity
immune system
adaptive immune response
immune surveillance
vaccine response
antigen processing
pathogen defense
activation of helper T cells
initiation of immune response
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:subunit
|
alpha chain
beta chain
|
|
gptkbp:bfsParent
|
gptkb:MHC_class_II
|
|
gptkbp:bfsLayer
|
7
|