Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:activatedBy |
gptkb:MAP_kinase_kinase_kinase_(MAP3K)
|
| gptkbp:alsoKnownAs |
gptkb:MEK
gptkb:MAP2K |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:RASopathies melanoma |
| gptkbp:biologicalProcess |
protein serine/threonine kinase activity
|
| gptkbp:discoveredBy |
gptkb:Lewis_Cantley
|
| gptkbp:EC_number |
2.7.12.2
|
| gptkbp:function |
phosphorylates MAP kinases
|
| gptkbp:gene |
gptkb:MAP2K1
gptkb:MAP2K2 |
| https://www.w3.org/2000/01/rdf-schema#label |
MAP kinase kinase (MEK)
|
| gptkbp:inhibitedBy |
gptkb:MEK_inhibitors
|
| gptkbp:involvedIn |
gptkb:MAPK/ERK_pathway
|
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:partOf |
signal transduction
|
| gptkbp:role |
cell differentiation
cell proliferation cell survival |
| gptkbp:substrate |
gptkb:MAPK_(ERK)
|
| gptkbp:target |
gptkb:trametinib
gptkb:cobimetinib gptkb:selumetinib gptkb:binimetinib |
| gptkbp:bfsParent |
gptkb:MAP_kinase
|
| gptkbp:bfsLayer |
6
|