low-density lipoprotein receptor family
GPTKB entity
Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredBy |
gptkb:Michael_S._Brown
gptkb:Joseph_L._Goldstein |
| gptkbp:domain |
transmembrane domain
cytoplasmic tail EGF-precursor homology domain ligand-binding domain beta-propeller domain |
| gptkbp:foundIn |
animals
|
| gptkbp:function |
cholesterol homeostasis
endocytosis of lipoproteins |
| gptkbp:GO_term |
GO:0005041 (low-density lipoprotein receptor activity)
GO:0006898 (receptor-mediated endocytosis) |
| gptkbp:member |
gptkb:LRP5
gptkb:LRP6 LDLR (low-density lipoprotein receptor) LRP1 (LDL receptor-related protein 1) LRP2 (megalin) LRP8 (ApoER2) SORL1 (sortilin-related receptor) VLDLR (very low-density lipoprotein receptor) |
| gptkbp:orthologIn |
C. elegans LRP-1
Drosophila LpR1 |
| gptkbp:relatedTo |
gptkb:familial_hypercholesterolemia
atherosclerosis |
| gptkbp:bfsParent |
gptkb:VLDL_receptor
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
low-density lipoprotein receptor family
|