|
gptkbp:instanceOf
|
transcription factor
nuclear receptor
|
|
gptkbp:activatedBy
|
gptkb:22(R)-hydroxycholesterol
gptkb:24(S),25-epoxycholesterol
gptkb:27-hydroxycholesterol
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:NR1H2
gptkb:NR1H3
|
|
gptkbp:expressedIn
|
liver
adipose tissue
macrophages
intestine
|
|
gptkbp:formsHeterodimerWith
|
gptkb:Retinoid_X_Receptor
|
|
gptkbp:hasIsoform
|
gptkb:LXRα
gptkb:LXRβ
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Liver X Receptor
|
|
gptkbp:involvedIn
|
gptkb:diabetes
atherosclerosis
neurodegenerative diseases
fatty liver disease
|
|
gptkbp:ligand
|
oxysterol
|
|
gptkbp:memberOf
|
gptkb:nuclear_receptor_subfamily_1_group_H
|
|
gptkbp:orthologInMouse
|
gptkb:Nr1h2
gptkb:Nr1h3
|
|
gptkbp:PDB
|
gptkb:1P8D
gptkb:1UHL
|
|
gptkbp:regulates
|
gptkb:ApoE
gptkb:ABCA1
gptkb:CYP7A1
gptkb:SREBP-1c
lipid metabolism
inflammation
cholesterol metabolism
immune response
reverse cholesterol transport
fatty acid synthesis
glucose homeostasis
lipogenesis
gluconeogenesis
bile acid synthesis
HDL formation
VLDL secretion
inflammatory gene expression
triglyceride synthesis
|
|
gptkbp:subclassOf
|
intracellular receptor
ligand-activated transcription factor
|
|
gptkbp:symbol
|
gptkb:LXR
|
|
gptkbp:target
|
pharmaceutical research
|
|
gptkbp:bfsParent
|
gptkb:LXR
|
|
gptkbp:bfsLayer
|
6
|